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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Ceramide phosphoethanolamine synthase ： ウィキペディア英語版 Ceramide phosphoethanolamine synthase In enzymology, a ceramide phosphoethanolamine synthase (EC 2.7.8.-) is an enzyme that catalyzes the chemical reaction :a ceramide + a phosphoethanolamine head group donor $\backslash rightleftharpoons$ a ceramide-phosphoethanolamine + side product Ceramide phosphoethanolamine (CPE) is a sphingolipid consisted of a ceramide and a phosphatidylethanolamine. Thus, this class of enzymes uses ceramide and a donor molecule for phosphoethanolamine as substrates to produce a ceramide phosphoethanolamine and a side product. The head group donor for phosphoethanolamine can be either phosphatidylethanolamine or CDP-ethanolamine, thus the side product is either a 1,2-diacylglycerol or a CMP, respectively. This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. ==Mammalian Ceramide Phosphoethanolamine Synthases== In mammalian cells, two CPE synthase activities have been described, one resides in the endoplasmic reticulum, and the other one is associated with the plasma membrane.〔Malgat, M., Maurice, A., and Baraud, J. (1986) Sphingomyelin and ceramide-phosphoethanolamine synthesis by microsomes and plasma membranes from rat liver and brain. ''J. Lipid Res''. 27, 251–260〕〔Malgat, M., Maurice, A., and Baraud, J. (1987) Sidedness of ceramidephosphoethanolamine synthesis on rat liver and brain microsomal membranes. ''J. Lipid Res''. 28, 138–143〕〔Maurice, A., Malgat, M., and Baraud, J. (1989) Sidedness of ceramidephosphoethanolamine synthesis on rat liver plasma membrane. ''Biochimie'' 71, 373–378〕〔Ternes, P., Brouwers, J. F., van den Dikkenberg, J., and Holthuis, J. C. (2009) Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase. ''J. Lipid Res''. 50, 2270–2277〕〔Vacaru, A. M., Tafesse, F. G., Ternes, P., Kondylis, V., Hermansson, M., Browers, J. F. H. M., Somerharju, P., Rabouille, C., and Holthuis, J. C. (2009) Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J. Cell. Biol. 185, 1013–1027〕 The endoplasmic reticulum-resident CPE synthase, SMSr, is identified as a monofunctional CPE synthase produces trace amounts of CPE.〔〔 On the other hand, mammalian CPE synthase that is on the plasma membrane, SMS2, is a bifunctional enzyme that produces both CPE and sphingomyelin, thus also functioning as a sphingomyelin synthase.〔 Both mammalian CPE synthases, SMS2 and SMSr, use phosphatidylethanolamine (PE) as head group donor and catalyzes the reaction :a ceramide + a phosphatidylethanolamine $\backslash rightleftharpoons$ a ceramide-phosphoethanolamine + 1,2-diacylglycerol 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Ceramide phosphoethanolamine synthase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.